Myrtle was an old woman Denzel dated in Two Weeks Notice until he learned that her mother is still alive and much older than her daughter. Myrtle revealed that she has a grandson who went to Tulane University on a full scholarship. When Denzel went for Myrtle's mother, she and her daughter get into a fight until Denzel settled things between the two and they had a threesome. However, Myrtle and her mother both died (coincidentally at the same time) as Denzel shut their eyelids and left them.
Myrtle and her mother are then seen in Heaven being lined up to be greeted by God in the final scene.